Trimethoprim resistant dihydrofolate reductases in normal faecal flora isolated in India
نویسندگان
چکیده
منابع مشابه
Protein expression in Escherichia coli minicells containing recombinant plasmids specifying trimethoprim-resistant dihydrofolate reductases.
Deoxyribonucleic acid fragments containing the structural genes for several trimethoprim-resistant dihydrofolate reductases from naturally occurring plasmids were inserted into small cloning vehicles. The genetic expression of these hybrid plasmids was studied in purified Escherichia coli minicells. The type I dihydrofolate reductase, encoded by plasmid R483 and residing within transposon 7 (Tn...
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متن کاملLow trimethoprim susceptibility of anaerobic bacteria due to insensitive dihydrofolate reductases.
All the 28 Bacteroides fragilis strains investigated were susceptible to sulfamethoxazole (minimal inhibitory concentration < 16 mug/ml) and resistant to trimethoprim (TMP; minimal inhibitory concentration > 4 mug/ml). Synergism between sulfamethoxazole and TMP was present in all strains at a ratio of 1:1. The few clostridia investigated proved more resistant to both compounds. Dihydrofolate re...
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ژورنال
عنوان ژورنال: Epidemiology and Infection
سال: 1994
ISSN: 0950-2688,1469-4409
DOI: 10.1017/s0950268800051670